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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731014
Species: Mus musculus
RGD Object: Gene
Symbol: Ccn2
Name: cellular communication network factor 2
Acc ID: CHEBI:4031
Term: cyclosporin A
Definition: A cyclic nonribosomal peptide of eleven amino acids; an immunosuppressant drug widely used in post-allogeneic organ transplant to reduce the activity of the patient's immune system, and therefore the risk of organ rejection. Also causes reversible inhibition of immunocompetent lymphocytes in the G0- and G1-phase of the cell cycle.
Chemical ID: MESH:D016572
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccn2increases expressionEXP 6480464CTDCyclosporine results in increased expression of CCN2 mRNAPMID:21354196
Ccn2multiple interactionsEXP 6480464CTDCyclosporine results in increased expression of and results in increased secretion of CCN2 proteinPMID:21354196
Ccn2affects expressionISOCcn2 (Rattus norvegicus)6480464CTDCyclosporine affects the expression of CCN2 mRNA; Cyclosporine affects the expression of CCN2 proteinPMID:24971338
Ccn2affects expressionISOCCN2 (Homo sapiens)6480464CTDCyclosporine affects the expression of CCN2 mRNAPMID:20106945
Ccn2decreases expressionISOCcn2 (Rattus norvegicus)6480464CTDCyclosporine results in decreased expression of CCN2 mRNAPMID:21865292
Ccn2decreases expressionISOCCN2 (Homo sapiens)6480464CTDCyclosporine results in decreased expression of CCN2 mRNA; Cyclosporine results in decreased expression of CTGF mRNAPMID:25562108 PMID:27989131 PMID:34681664
Ccn2increases expressionISOCCN2 (Homo sapiens)6480464CTDCyclosporine results in increased expression of CCN2 mRNAPMID:21632981
Ccn2multiple interactionsISOCCN2 (Homo sapiens)6480464CTD[Cyclosporine co-treated with Cholic Acids] affects the expression of CCN2 mRNAPMID:27344345
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