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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731014
Species: Mus musculus
RGD Object: Gene
Symbol: Ccn2
Name: cellular communication network factor 2
Acc ID: CHEBI:27584
Term: aldosterone
Definition: A pregnane-based steroidal hormone produced by the outer-section (zona glomerulosa) of the adrenal cortex in the adrenal gland, and acts on the distal tubules and collecting ducts of the kidney to cause the conservation of sodium, secretion of potassium, increased water retention, and increased blood pressure. The overall effect of aldosterone is to increase reabsorption of ions and water in the kidney.
Chemical ID: MESH:D000450
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccn2increases expressionISOCcn2 (Rattus norvegicus)6480464CTDAldosterone results in increased expression of CCN2 proteinPMID:17278980
Ccn2increases expressionISOCCN2 (Homo sapiens)6480464CTDAldosterone results in increased expression of CCN2 mRNAPMID:30809271
Ccn2multiple interactionsISOCcn2 (Rattus norvegicus)6480464CTDSpironolactone inhibits the reaction [Aldosterone results in increased expression of CCN2 protein]PMID:17278980
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