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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731013
Species: Homo sapiens
RGD Object: Gene
Symbol: CCN2
Name: cellular communication network factor 2
Acc ID: CHEBI:16243
Term: quercetin
Definition: A pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is one of the most abundant flavonoids in edible vegetables, fruit and wine.
Chemical ID: MESH:D011794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CCN2decreases expressionEXP 6480464CTDQuercetin results in decreased expression of CCN2 mRNAPMID:21632981
CCN2multiple interactionsISOCcn2 (Rattus norvegicus)6480464CTDQuercetin inhibits the reaction [Carbon Tetrachloride results in increased expression of CCN2 mRNA]; Quercetin inhibits the reaction [Isoproterenol results in increased expression of CCN2 mRNA]; Quercetin inhibits the reaction [Isoproterenol results in increased expression of CCN2 protein]; Quercetin inhibits the reaction [TGFB1 protein results in increased expression of CCN2 mRNA]PMID:15573758 PMID:22989100 PMID:24117263
CCN2multiple interactionsISOCcn2 (Mus musculus)6480464CTDQuercetin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of CCN2 mRNA]PMID:22915297
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