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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731007
Species: Mus musculus
RGD Object: Gene
Symbol: Ptgs2
Name: prostaglandin-endoperoxide synthase 2
Acc ID: CHEBI:47381
Term: diclofenac
Definition: A monocarboxylic acid consisting of phenylacetic acid having a (2,6-dichlorophenyl)amino group at the 2-position.
Chemical ID: MESH:D004008
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ptgs2decreases activityEXP 6480464CTDDiclofenac results in decreased activity of PTGS2 proteinPMID:12242329
Ptgs2increases expressionEXP 6480464CTDDiclofenac results in increased expression of PTGS2 proteinPMID:15626590
Ptgs2multiple interactionsEXP 6480464CTDAcetaminophen inhibits the reaction [Diclofenac results in increased expression of PTGS2 protein]; Diclofenac binds to and results in decreased activity of PTGS2 protein; Diclofenac inhibits the reaction [Freund's Adjuvant results in increased expression of PTGS2 protein]PMID:12925531 PMID:15626590 PMID:31926916
Ptgs2decreases activityISOPtgs2 (Rattus norvegicus)6480464CTDDiclofenac results in decreased activity of PTGS2 proteinPMID:9258749
Ptgs2decreases activityISOPTGS2 (Homo sapiens)6480464CTDDiclofenac results in decreased activity of PTGS2 proteinPMID:17164136
Ptgs2decreases expressionISOPTGS2 (Homo sapiens)6480464CTDDiclofenac results in decreased expression of PTGS2 mRNAPMID:19192274
Ptgs2increases expressionISOPtgs2 (Rattus norvegicus)6480464CTDDiclofenac results in increased expression of PTGS2 mRNA; Diclofenac results in increased expression of PTGS2 proteinPMID:19031110 PMID:9851595
Ptgs2increases expressionISOPTGS2 (Homo sapiens)6480464CTDDiclofenac results in increased expression of PTGS2 mRNAPMID:10594327 PMID:16793607 PMID:32816093
Ptgs2multiple interactionsISOPtgs2 (Rattus norvegicus)6480464CTDDiclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of PTGS2 mRNA]PMID:23939143
Ptgs2multiple interactionsISOPTGS2 (Homo sapiens)6480464CTDDiclofenac inhibits the reaction [IL1B protein results in increased activity of PTGS2 protein]; Diclofenac inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]PMID:15489888 PMID:15705740
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