An aromatic ether having phenyl and 2-methylsulfonamido-5-nitrophenyl as the two aryl groups.
Chemical ID:
MESH:C012655
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
[[(4-(((2-(3-fluoro-4-(trifluoromethyl)phenyl)-4-methyl-1,3-thiazol-5-yl)methyl)sulfanyl)-2-methylphenoxy)acetic acid binds to and results in increased activity of PPARD protein] co-treated with [nimesulide results in decreased activity of PTGS2 protein]] results in increased expression of KRT10 mRNA; [[nimesulide results in decreased activity of PTGS2 protein] co-treated with [(4-(((2-(3-fluoro-4-(trifluoromethyl)phenyl)-4-methyl-1,3-thiazol-5-yl)methyl)sulfanyl)-2-methylphenoxy)acetic acid binds to and results in increased activity of PPARD protein]] results in decreased abundance of Dinoprostone; [nimesulide results in decreased activity of PTGS2 protein] which results in decreased abundance of Dinoprostone; [nimesulide results in decreased activity of PTGS2 protein] which results in increased expression of CCL2 mRNA; [nimesulide results in decreased activity of PTGS2 protein] which results in increased expression of CXCL10 mRNA; [nimesulide results in decreased activity of PTGS2 protein] which results in increased expression of CXCL11 mRNA; [nimesulide results in decreased activity of PTGS2 protein] which results in increased expression of CXCL9 mRNA; [nimesulide results in decreased activity of PTGS2 protein] which results in increased expression of IFNB1 mRNA; [nimesulide results in decreased activity of PTGS2 protein] which results in increased expression of IFNG mRNA; [nimesulide results in decreased activity of PTGS2 protein] which results in increased expression of IL23A mRNA; [nimesulide results in decreased activity of PTGS2 protein] which results in increased expression of TNFSF11 mRNA; [nimesulide results in decreased activity of PTGS2 protein] which results in increased expression of XCL1 mRNA; [nimesulide results in decreased expression of PTGS2] promotes the reaction [FAAH affects the metabolism of anandamide]; [nimesulide results in decreased expression of PTGS2] which results in increased abundance of Arachidonic Acid; nimesulide binds to and results in decreased activity of PTGS2 protein; nimesulide inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in increased expression of PTGS2 mRNA]; nimesulide inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in increased expression of PTGS2 protein]; nimesulide inhibits the reaction [[soluble tachyzoite antigen, Toxoplasma gondii results in increased expression of PTGS2 mRNA] which results in increased abundance of Dinoprostone]; nimesulide inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; nimesulide inhibits the reaction [soluble tachyzoite antigen, Toxoplasma gondii results in increased expression of PTGS2 mRNA]; PPARD protein affects the reaction [[nimesulide results in decreased activity of PTGS2 protein] which results in decreased abundance of Dinoprostone]; PPARD protein mutant form inhibits the reaction [[nimesulide results in decreased activity of PTGS2 protein] which results in decreased abundance of Dinoprostone]; PTGS2 affects the reaction [nimesulide results in decreased expression of VEGFA protein]; PTGS2 inhibits the reaction [nimesulide results in increased uptake of Hexoses]
[nimesulide results in decreased activity of PTGS2 protein] which results in increased susceptibility to Morphine; [nimesulide results in decreased expression of PTGS2 protein] which results in decreased abundance of Dinoprostone; [nimesulide results in decreased expression of PTGS2] which results in increased activity of anandamide; nimesulide inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PTGS2 protein]; nimesulide inhibits the reaction [Dietary Fats results in increased expression of PTGS2 mRNA]; nimesulide inhibits the reaction [Dietary Fats results in increased expression of PTGS2]; nimesulide promotes the reaction [Carrageenan results in increased expression of PTGS2 protein]
[nimesulide results in decreased activity of PTGS2 protein] which results in decreased abundance of Dinoprostone; nimesulide inhibits the reaction [[4-Nitroquinoline-1-oxide co-treated with HRAS] results in increased expression of PTGS2 mRNA]; nimesulide inhibits the reaction [ciglitazone promotes the reaction [PPARA protein results in increased expression of PTGS2 mRNA]]; nimesulide inhibits the reaction [ciglitazone promotes the reaction [PPARG protein results in increased expression of PTGS2 mRNA]]; nimesulide inhibits the reaction [ciglitazone results in increased expression of PTGS2 mRNA]; nimesulide inhibits the reaction [ciglitazone results in increased expression of PTGS2 protein]; nimesulide inhibits the reaction [pirinixic acid promotes the reaction [PPARA protein results in increased expression of PTGS2 mRNA]]; nimesulide inhibits the reaction [pirinixic acid promotes the reaction [PPARG protein results in increased expression of PTGS2 mRNA]]; nimesulide inhibits the reaction [pirinixic acid results in increased expression of PTGS2 mRNA]; nimesulide inhibits the reaction [pirinixic acid results in increased expression of PTGS2 protein]; nimesulide inhibits the reaction [PTGS2 protein affects the chemical synthesis of and affects the abundance of Dinoprostone]; nimesulide inhibits the reaction [PTGS2 protein results in increased metabolism of Arachidonic Acid]; nimesulide inhibits the reaction [PTGS2 results in decreased expression of CDKN2C mRNA]; nimesulide inhibits the reaction [PTGS2 results in increased expression of C1QB mRNA]
