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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731007
Species: Mus musculus
RGD Object: Gene
Symbol: Ptgs2
Name: prostaglandin-endoperoxide synthase 2
Acc ID: CHEBI:39285
Term: chloropicrin
Definition: A C-nitro compound that is nitromethane in which all three hydrogens are replaced by chlorines. It is a severe irritant, and can cause immediate, severe inflammation of the eyes, nose and throat, and significant injuries to the upper and lower respiratory tract. Formerly stockpiled as a chemical warfare agent, it has been widely used in the US as a soil fumigant, particularly for strawberry crops. It is not approved for use within the European Union.
Chemical ID: MESH:C100187
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ptgs2affects expressionISOPTGS2 (Homo sapiens)6480464CTDchloropicrin affects the expression of PTGS2 mRNAPMID:26352163
Ptgs2decreases expressionISOPTGS2 (Homo sapiens)6480464CTDchloropicrin results in decreased expression of PTGS2 mRNAPMID:28476498
Ptgs2increases expressionISOPTGS2 (Homo sapiens)6480464CTDchloropicrin results in increased expression of PTGS2 proteinPMID:31884112
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