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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731007
Species: Mus musculus
RGD Object: Gene
Symbol: Ptgs2
Name: prostaglandin-endoperoxide synthase 2
Acc ID: CHEBI:36904
Term: elemental selenium
Definition: null
Chemical ID: MESH:D012643
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ptgs2multiple interactionsEXP 6480464CTDPPARG protein promotes the reaction [Selenium inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 protein]]; Selenium deficiency promotes the reaction [[Lipopolysaccharides results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; Selenium deficiency promotes the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; Selenium inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 protein]PMID:11978490 PMID:17439952
Ptgs2multiple interactionsISOPtgs2 (Rattus norvegicus)6480464CTD[Sodium Selenite results in increased abundance of Selenium] inhibits the reaction [bisphenol A results in increased expression of PTGS2 mRNA]; [Vitamin E co-treated with Selenium] results in decreased expression of PTGS2 mRNA; [Vitamin E co-treated with Selenium] results in decreased expression of PTGS2 proteinPMID:22223226 PMID:30526071
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