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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731007
Species: Mus musculus
RGD Object: Gene
Symbol: Ptgs2
Name: prostaglandin-endoperoxide synthase 2
Acc ID: CHEBI:34317
Term: 3,3',4,4',5-pentachlorobiphenyl
Definition: A pentachlorobiphenyl in which the chlorines are located at the 3, 4, 5, 3', and 4' positions.
Chemical ID: MESH:C023035
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ptgs2affects expressionISOPTGS2 (Homo sapiens)6480464CTD3,4,5,3',4'-pentachlorobiphenyl affects the expression of PTGS2 mRNAPMID:21703328
Ptgs2increases expressionISOPtgs2 (Rattus norvegicus)6480464CTD3,4,5,3',4'-pentachlorobiphenyl results in increased expression of PTGS2 mRNAPMID:23196670
Ptgs2increases expressionISOPTGS2 (Homo sapiens)6480464CTD3,4,5,3',4'-pentachlorobiphenyl results in increased expression of PTGS2 mRNA; 3,4,5,3',4'-pentachlorobiphenyl results in increased expression of PTGS2 proteinPMID:21513769 PMID:22262711 PMID:35618242
Ptgs2multiple interactionsISOPTGS2 (Homo sapiens)6480464CTD2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of PTGS2 mRNA]; [Estradiol co-treated with 3,4,5,3',4'-pentachlorobiphenyl] results in increased expression of PTGS2 mRNA; [Estradiol co-treated with 3,4,5,3',4'-pentachlorobiphenyl] results in increased expression of PTGS2 protein; alpha-naphthoflavone inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of PTGS2 mRNA]; Estradiol promotes the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of PTGS2 mRNA]; fulvestrant promotes the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of PTGS2 mRNA]PMID:21513769 PMID:22262711
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