GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Ptgs2 | increases expression | EXP | | 6480464 | CTD | Nicotine results in increased expression of PTGS2 mRNA | PMID:16254210 PMID:17456735 | Ptgs2 | increases activity | ISO | PTGS2 (Homo sapiens) | 6480464 | CTD | Nicotine results in increased activity of PTGS2 protein | PMID:17003101 PMID:18805435 | Ptgs2 | increases expression | ISO | Ptgs2 (Rattus norvegicus) | 6480464 | CTD | Nicotine results in increased expression of PTGS2 mRNA; Nicotine results in increased expression of PTGS2 protein | PMID:18068289 PMID:19673871 | Ptgs2 | increases expression | ISO | PTGS2 (Homo sapiens) | 6480464 | CTD | Nicotine results in increased expression of PTGS2 mRNA; Nicotine results in increased expression of PTGS2 protein | PMID:17003101 PMID:17369603 PMID:18986645 PMID:20727180 | Ptgs2 | multiple interactions | ISO | Ptgs2 (Rattus norvegicus) | 6480464 | CTD | Acetylcysteine inhibits the reaction [Nicotine results in increased expression of PTGS2 protein]; ferulic acid inhibits the reaction [Nicotine results in increased expression of PTGS2 protein] | PMID:18068289 | Ptgs2 | multiple interactions | ISO | PTGS2 (Homo sapiens) | 6480464 | CTD | [4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide results in decreased activity of PTGS2 protein] inhibits the reaction [Nicotine results in increased abundance of Dinoprostone]; [Atenolol binds to and results in decreased activity of ADRB1 protein] inhibits the reaction [Nicotine results in increased expression of PTGS2 protein]; [ICI 118551 binds to and results in decreased activity of ADRB2 protein] inhibits the reaction [Nicotine results in increased expression of PTGS2 protein]; [ICI 118551 binds to and results in decreased activity of ADRB2 protein] inhibits the reaction [Nicotine results in increased expression of PTGS2]; [Lipopolysaccharides co-treated with Nicotine] results in increased expression of PTGS2 mRNA; [Lipopolysaccharides co-treated with Nicotine] results in increased expression of PTGS2 protein; [U 0126 results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] inhibits the reaction [Nicotine results in increased expression of PTGS2]; Curcumin inhibits the reaction [Nicotine results in increased expression of PTGS2 protein]; lipopolysaccharide, E. coli O26-B6 promotes the reaction [Nicotine results in increased expression of PTGS2 mRNA]; Nicotine promotes the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of PTGS2 mRNA]; Propranolol inhibits the reaction [Nicotine results in increased activity of PTGS2 protein]; resveratrol inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of PTGS2 protein]; SIRT1 protein inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of PTGS2 mRNA]; SIRT1 protein inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of PTGS2 protein]; Staurosporine inhibits the reaction [Nicotine results in increased expression of PTGS2] | PMID:17003101 PMID:17369603 PMID:18805435 PMID:18986645 PMID:20727180 PMID:23199342 | | ||||||||||||||||||||||
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