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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731006
Species: Homo sapiens
RGD Object: Gene
Symbol: PTGS2
Name: prostaglandin-endoperoxide synthase 2
Acc ID: CHEBI:4806
Term: (-)-epigallocatechin 3-gallate
Definition: A gallate ester obtained by the formal condensation of gallic acid with the (3R)-hydroxy group of (-)-epigallocatechin.
Chemical ID: MESH:C045651
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PTGS2decreases expressionEXP 6480464CTDepigallocatechin gallate results in decreased expression of PTGS2 mRNAPMID:16084531
PTGS2increases expressionEXP 6480464CTDepigallocatechin gallate results in increased expression of PTGS2 proteinPMID:15210717
PTGS2multiple interactionsEXP 6480464CTD1-Butanol inhibits the reaction [epigallocatechin gallate results in increased expression of PTGS2 protein]; epigallocatechin gallate inhibits the reaction [Glucose results in increased expression of PTGS2 mRNA]; epigallocatechin gallate inhibits the reaction [Glucose results in increased expression of PTGS2 protein]; Go 6976 inhibits the reaction [epigallocatechin gallate results in increased expression of PTGS2 protein]; Go 6976 inhibits the reaction [PLD2 protein promotes the reaction [epigallocatechin gallate results in increased expression of PTGS2 protein]]; PLD1 protein promotes the reaction [epigallocatechin gallate results in increased expression of PTGS2 protein]; PLD2 protein promotes the reaction [epigallocatechin gallate results in increased expression of PTGS2 protein]; Propranolol promotes the reaction [epigallocatechin gallate results in increased expression of PTGS2 protein]; SB 203580 inhibits the reaction [epigallocatechin gallate results in increased expression of PTGS2 protein]; SB 203580 inhibits the reaction [PLD2 protein promotes the reaction [epigallocatechin gallate results in increased expression of PTGS2 protein]]PMID:15210717 PMID:19557821
PTGS2increases expressionISOPtgs2 (Rattus norvegicus)6480464CTDepigallocatechin gallate results in increased expression of PTGS2 proteinPMID:15210717
PTGS2multiple interactionsISOPtgs2 (Rattus norvegicus)6480464CTD1-Butanol inhibits the reaction [epigallocatechin gallate results in increased expression of PTGS2 protein]; epigallocatechin gallate promotes the reaction [Sulindac inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of PTGS2 protein]]; Go 6976 inhibits the reaction [epigallocatechin gallate results in increased expression of PTGS2 protein]; SB 203580 inhibits the reaction [epigallocatechin gallate results in increased expression of PTGS2 protein]PMID:15210717 PMID:29999212
PTGS2multiple interactionsISOPtgs2 (Mus musculus)6480464CTD[epigallocatechin gallate co-treated with polylactic acid-polyglycolic acid copolymer analog] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of PTGS2 mRNA]; epigallocatechin gallate inhibits the reaction [Carbon Tetrachloride results in increased expression of PTGS2 mRNA]; epigallocatechin gallate inhibits the reaction [Carbon Tetrachloride results in increased expression of PTGS2 protein]PMID:20438794 PMID:23717041
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