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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731006
Species: Homo sapiens
RGD Object: Gene
Symbol: PTGS2
Name: prostaglandin-endoperoxide synthase 2
Acc ID: CHEBI:31823
Term: mercury dichloride
Definition: A mercury coordination entity made up of linear triatomic molecules in which a mercury atom is bonded to two chlorines. Water-soluble, it is highly toxic. Once used in a wide variety of applications, including preserving wood and anatomical specimens, embalming and disinfecting, as an intensifier in photography, as a mordant for rabbit and beaver furs, and freeing gold from lead, its use has markedly declined as less toxic alternatives have been developed.
Chemical ID: MESH:D008627
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PTGS2increases expressionISOPtgs2 (Rattus norvegicus)6480464CTDMercuric Chloride results in increased expression of PTGS2 mRNA; Mercuric Chloride results in increased expression of PTGS2 proteinPMID:20228412 PMID:23415682 PMID:28987480
PTGS2multiple interactionsISOPtgs2 (Rattus norvegicus)6480464CTDacetovanillone inhibits the reaction [Mercuric Chloride results in increased expression of PTGS2 mRNA]; SB 203580 inhibits the reaction [Mercuric Chloride results in increased expression of PTGS2 mRNA]; tempol inhibits the reaction [Mercuric Chloride results in increased expression of PTGS2 mRNA]; U 0126 inhibits the reaction [Mercuric Chloride results in increased expression of PTGS2 mRNA]PMID:23415682
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