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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731006
Species: Homo sapiens
RGD Object: Gene
Symbol: PTGS2
Name: prostaglandin-endoperoxide synthase 2
Acc ID: CHEBI:31638
Term: fulvestrant
Definition: A 3-hydroxy steroid that is 17beta-estradiol in which the 7alpha hydrogen has been replaced by a nonyl group in which one of the hydrogens of the terminal methyl has been replaced by a (4,4,5,5,5-pentafluoropentyl)sulfinyl group. An estrogen receptor antagonist, it is used in the treatment of breast cancer.
Chemical ID: MESH:C070081
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PTGS2increases expressionEXP 6480464CTDFulvestrant results in increased expression of PTGS2 mRNAPMID:31646340
PTGS2multiple interactionsEXP 6480464CTDarsenite inhibits the reaction [Fulvestrant results in increased expression of PTGS2 mRNA]; Cadmium inhibits the reaction [Fulvestrant results in increased expression of PTGS2 mRNA]; Fulvestrant inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of PTGS2 protein]; Fulvestrant inhibits the reaction [bisphenol A results in increased expression of PTGS2 mRNA]; Fulvestrant inhibits the reaction [Estradiol results in decreased expression of PTGS2 mRNA]; Fulvestrant inhibits the reaction [Hexachlorobenzene results in increased expression of PTGS2 protein]; Fulvestrant promotes the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of PTGS2 mRNA]; Fulvestrant promotes the reaction [Chlorpyrifos results in increased expression of PTGS2 protein]PMID:20951759 PMID:21513769 PMID:26546977 PMID:31646340 PMID:32526215
PTGS2multiple interactionsISOPtgs2 (Mus musculus)6480464CTDFulvestrant inhibits the reaction [4,4'-bisphenol F results in increased expression of PTGS2 mRNA]; Fulvestrant inhibits the reaction [4,4'-bisphenol F results in increased expression of PTGS2 protein]; Fulvestrant inhibits the reaction [Estradiol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]]PMID:15256495 PMID:32044397
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