A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID:
MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Cisplatin results in increased expression of PTGS2 protein]; [Cisplatin co-treated with ciglitazone] results in decreased expression of PTGS2; [Cisplatin co-treated with Fluorouracil] affects the expression of PTGS2 protein; [Cisplatin co-treated with jinfukang] results in increased expression of PTGS2 mRNA; [PTGS2 protein results in increased expression of ABCC1 protein] which results in increased susceptibility to Cisplatin; [PTGS2 protein results in increased expression of ABCC2 protein] which results in increased susceptibility to Cisplatin; [tetraarsenic tetrasulfide co-treated with Cisplatin] results in decreased expression of PTGS2 protein; astilbin inhibits the reaction [Cisplatin results in increased expression of PTGS2 protein]; PPARGC1A protein affects the reaction [SRT1720 inhibits the reaction [Cisplatin results in increased expression of PTGS2 protein]]; SRT1720 inhibits the reaction [Cisplatin results in increased expression of PTGS2 protein]
Cisplatin results in increased expression of PTGS2; Cisplatin results in increased expression of PTGS2 mRNA; Cisplatin results in increased expression of PTGS2 protein
Grape Seed Proanthocyanidins inhibits the reaction [Cisplatin results in increased expression of PTGS2 mRNA]; Resveratrol inhibits the reaction [Cisplatin results in increased expression of PTGS2 protein]
[5-aminoisoquinoline co-treated with Cisplatin] results in decreased expression of PTGS2 protein; anemoside B4 inhibits the reaction [Cisplatin results in increased expression of PTGS2 protein]; Chlorogenic Acid inhibits the reaction [Cisplatin results in increased expression of PTGS2 protein]; Cisplatin inhibits the reaction [[9,10-Dimethyl-1,2-benzanthracene co-treated with Croton Oil] results in increased expression of PTGS2 mRNA]; Cisplatin inhibits the reaction [[9,10-Dimethyl-1,2-benzanthracene co-treated with Croton Oil] results in increased expression of PTGS2 protein]; Cisplatin promotes the reaction [NPPC protein inhibits the reaction [[9,10-Dimethyl-1,2-benzanthracene co-treated with Croton Oil] results in increased expression of PTGS2 mRNA]]; Cisplatin promotes the reaction [NPPC protein inhibits the reaction [[9,10-Dimethyl-1,2-benzanthracene co-treated with Croton Oil] results in increased expression of PTGS2 protein]]; diphenylmethyl selenocyanate inhibits the reaction [Cisplatin results in increased expression of PTGS2 protein]; ferrostatin-1 inhibits the reaction [Cisplatin results in increased expression of PTGS2 mRNA]; ferrostatin-1 inhibits the reaction [Cisplatin results in increased expression of PTGS2 protein]; gap 27 peptide inhibits the reaction [Cisplatin results in increased expression of PTGS2 mRNA]; gap 27 peptide inhibits the reaction [Cisplatin results in increased expression of PTGS2 protein]; IL6 gene mutant form promotes the reaction [Cisplatin results in increased expression of PTGS2 mRNA]; Luteolin inhibits the reaction [Cisplatin results in increased expression of PTGS2 protein]; Minocycline inhibits the reaction [Cisplatin results in increased expression of PTGS2 mRNA]; NPPC protein promotes the reaction [Cisplatin inhibits the reaction [[9,10-Dimethyl-1,2-benzanthracene co-treated with Croton Oil] results in increased expression of PTGS2 mRNA]]; NPPC protein promotes the reaction [Cisplatin inhibits the reaction [[9,10-Dimethyl-1,2-benzanthracene co-treated with Croton Oil] results in increased expression of PTGS2 protein]]; PTGS2 protein promotes the reaction [Cisplatin results in increased expression of IL1B protein]; PTGS2 protein promotes the reaction [Cisplatin results in increased expression of TNF protein]
