GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | PTGS2 | increases expression | EXP | | 6480464 | CTD | Ethanol results in increased expression of PTGS2 mRNA; Ethanol results in increased expression of PTGS2 protein | PMID:26220687 | PTGS2 | multiple interactions | EXP | | 6480464 | CTD | CAT protein inhibits the reaction [Ethanol promotes the reaction [sodium arsenite results in increased expression of PTGS2 mRNA]]; CAT protein inhibits the reaction [sodium arsenite promotes the reaction [Ethanol results in increased expression of PTGS2 mRNA]]; Cyclosporine inhibits the reaction [Ethanol results in increased expression of PTGS2 protein]; Cyclosporine inhibits the reaction [sodium arsenite promotes the reaction [Ethanol results in increased expression of PTGS2 protein]]; Ethanol promotes the reaction [sodium arsenite results in increased expression of PTGS2 mRNA]; Ethanol promotes the reaction [sodium arsenite results in increased expression of PTGS2 protein]; sodium arsenite promotes the reaction [Ethanol results in increased expression of PTGS2 mRNA]; sodium arsenite promotes the reaction [Ethanol results in increased expression of PTGS2 protein] | PMID:26220687 | PTGS2 | affects expression | ISO | Ptgs2 (Mus musculus) | 6480464 | CTD | Ethanol affects the expression of PTGS2 mRNA | PMID:30319688 | PTGS2 | increases expression | ISO | Ptgs2 (Rattus norvegicus) | 6480464 | CTD | Ethanol results in increased expression of PTGS2 mRNA; Ethanol results in increased expression of PTGS2 protein | PMID:17067360 PMID:22525864 PMID:26460608 PMID:26522475 PMID:30844427 PMID:33314588 PMID:35227807 PMID:36085217 PMID:36453646 | PTGS2 | increases expression | ISO | Ptgs2 (Mus musculus) | 6480464 | CTD | Ethanol results in increased expression of PTGS2 mRNA; Ethanol results in increased expression of PTGS2 protein | PMID:23500890 PMID:26970604 PMID:34864093 PMID:35526736 | PTGS2 | multiple interactions | ISO | Ptgs2 (Rattus norvegicus) | 6480464 | CTD | [2,4-dichlorophenoxyacetic acid isooctyl ester results in increased abundance of 2,4-Dichlorophenoxyacetic Acid] promotes the reaction [Ethanol results in increased expression of PTGS2 mRNA]; [Ethanol co-treated with Fish Oils] results in increased expression of PTGS2 protein; [manganese chloride results in increased abundance of Manganese] promotes the reaction [Ethanol results in increased expression of PTGS2 protein]; acetovanillone inhibits the reaction [Ethanol results in increased expression of PTGS2 protein]; Butylated Hydroxytoluene inhibits the reaction [Ethanol results in increased expression of PTGS2 mRNA]; Cannabinoids inhibits the reaction [Ethanol results in increased expression of PTGS2 mRNA]; Clofibrate inhibits the reaction [[Ethanol co-treated with Fish Oils] results in increased expression of PTGS2 protein]; Ethanol promotes the reaction [[2,4-dichlorophenoxyacetic acid isooctyl ester results in increased abundance of 2,4-Dichlorophenoxyacetic Acid] which results in increased expression of PTGS2 mRNA]; Ethanol promotes the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of PTGS2 protein]; Plant Extracts inhibits the reaction [Ethanol results in increased expression of PTGS2 mRNA]; Plant Extracts inhibits the reaction [Ethanol results in increased expression of PTGS2 protein]; tricarbonyldichlororuthenium (II) dimer inhibits the reaction [Ethanol results in increased expression of PTGS2 mRNA] | PMID:15016835 PMID:17067360 PMID:22525864 PMID:26460608 PMID:26522475 PMID:30844427 PMID:33314588 PMID:36085217 PMID:36453646 | PTGS2 | multiple interactions | ISO | Ptgs2 (Mus musculus) | 6480464 | CTD | [Ethanol co-treated with High Fructose Corn Syrup co-treated with lard] results in increased expression of PTGS2 protein; [Ethanol co-treated with Lipopolysaccharides] results in increased expression of PTGS2 protein; [Ethanol co-treated with Thioacetamide] results in increased expression of PTGS2 mRNA; [lard co-treated with Ethanol co-treated with High Fructose Corn Syrup] results in increased expression of PTGS2 protein; [sodium arsenite co-treated with Ethanol] results in increased expression of PTGS2 protein; costunolide inhibits the reaction [Ethanol results in increased expression of PTGS2 protein]; dehydrocostus lactone inhibits the reaction [Ethanol results in increased expression of PTGS2 protein]; diallyl disulfide inhibits the reaction [[Ethanol co-treated with Lipopolysaccharides] results in increased expression of PTGS2 protein]; diallyl disulfide inhibits the reaction [Ethanol results in increased expression of PTGS2 protein]; ferrostatin-1 inhibits the reaction [Ethanol results in increased expression of PTGS2 mRNA]; ferrostatin-1 inhibits the reaction [Ethanol results in increased expression of PTGS2 protein]; m-trifluoromethyl-diphenyl diselenide inhibits the reaction [[Ethanol co-treated with High Fructose Corn Syrup co-treated with lard] results in increased expression of PTGS2 protein]; m-trifluoromethyl-diphenyl diselenide inhibits the reaction [[lard co-treated with Ethanol co-treated with High Fructose Corn Syrup] results in increased expression of PTGS2 protein]; Omeprazole inhibits the reaction [Ethanol results in increased expression of PTGS2 protein]; TLR4 gene mutant form inhibits the reaction [Ethanol results in increased expression of PTGS2 protein] | PMID:21863215 PMID:23500890 PMID:26220687 PMID:26970604 PMID:34864093 PMID:35526736 PMID:37023972 PMID:37054933 | | ||||||||||||||||||||||
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