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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731006
Species: Homo sapiens
RGD Object: Gene
Symbol: PTGS2
Name: prostaglandin-endoperoxide synthase 2
Acc ID: CHEBI:15365
Term: acetylsalicylic acid
Definition: A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.
Chemical ID: MESH:D001241
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PTGS2affects response to substanceEXP 6480464CTDPTGS2 gene SNP affects the susceptibility to Aspirin; PTGS2 SNP affects the susceptibility to AspirinPMID:19755647 PMID:20485159
PTGS2decreases activityEXP 6480464CTDAspirin results in decreased activity of PTGS2 protein; Aspirin results in decreased activity of PTGS2 protein mutant formPMID:15843042 PMID:22245433
PTGS2decreases degradationEXP 6480464CTDAspirin results in decreased degradation of PTGS2 mRNAPMID:14742690
PTGS2decreases expressionEXP 6480464CTDAspirin results in decreased expression of PTGS2 mRNA; Aspirin results in decreased expression of PTGS2 proteinPMID:12781040 PMID:15861417 PMID:16336399 PMID:18197933 PMID:19880272
PTGS2increases expressionEXP 6480464CTDAspirin results in increased expression of PTGS2 mRNA; Aspirin results in increased expression of PTGS2 proteinPMID:14742690 PMID:17218764 PMID:32816093
PTGS2multiple interactionsEXP 6480464CTDAscorbic Acid inhibits the reaction [Aspirin results in increased expression of PTGS2 mRNA]; Aspirin inhibits the reaction [[Arachidonic Acid results in increased activity of PTGS2 protein] which results in increased susceptibility to Methamphetamine]; Aspirin inhibits the reaction [Arachidonic Acid results in increased activity of PTGS2 protein]; Aspirin inhibits the reaction [HMGB1 protein results in increased expression of PTGS2 protein]; Aspirin inhibits the reaction [PTGS2 protein results in increased susceptibility to Methamphetamine]; Aspirin inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]; Aspirin inhibits the reaction [TNF results in increased expression of PTGS2 mRNA]; Aspirin inhibits the reaction [TNF results in increased expression of PTGS2 protein]; Aspirin promotes the reaction [IL1A results in increased expression of PTGS2 mRNA]; Aspirin promotes the reaction [IL1A results in increased expression of PTGS2 protein]; IL1A promotes the reaction [Aspirin results in increased expression of PTGS2 mRNA]; IL1A promotes the reaction [Aspirin results in increased expression of PTGS2 protein]; SB 203580 inhibits the reaction [Aspirin results in decreased degradation of PTGS2 mRNA]; SB 203580 inhibits the reaction [Aspirin results in increased expression of PTGS2 mRNA]; SB 203580 inhibits the reaction [Aspirin results in increased expression of PTGS2 protein]PMID:14742690 PMID:15489888 PMID:17218764 PMID:19493461 PMID:21163909 PMID:34755645
PTGS2decreases expressionISOPtgs2 (Rattus norvegicus)6480464CTDAspirin results in decreased expression of PTGS2 proteinPMID:16310244
PTGS2increases expressionISOPtgs2 (Rattus norvegicus)6480464CTDAspirin results in increased expression of PTGS2; Aspirin results in increased expression of PTGS2 mRNA; Aspirin results in increased expression of PTGS2 proteinPMID:12231391 PMID:16804302 PMID:17595529 PMID:18482463
PTGS2increases expressionISOPtgs2 (Mus musculus)6480464CTDAspirin results in increased expression of PTGS2 mRNAPMID:10706128
PTGS2multiple interactionsISOPtgs2 (Rattus norvegicus)6480464CTD[Aspirin co-treated with Hydrochloric Acid] results in increased expression of PTGS2 mRNA; [telmisartan co-treated with Aspirin] inhibits the reaction [Streptozocin results in increased expression of PTGS2 protein]; Ampicillin inhibits the reaction [Aspirin promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PTGS2 mRNA]]; apple polyphenol extract inhibits the reaction [Aspirin results in increased expression of PTGS2 mRNA]; apple polyphenol extract inhibits the reaction [Aspirin results in increased expression of PTGS2 protein]; Aspirin inhibits the reaction [Carbon Tetrachloride results in increased expression of PTGS2 protein]; Aspirin inhibits the reaction [Streptozocin results in increased expression of PTGS2 protein]; Aspirin promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PTGS2 mRNA]PMID:18482463 PMID:20223228 PMID:21360558 PMID:21893697 PMID:9726391
PTGS2multiple interactionsISOPtgs2 (Mus musculus)6480464CTD[[Aspirin co-treated with Hydrochloric Acid] results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone; [Aspirin co-treated with Hydrochloric Acid] results in increased expression of PTGS2 mRNA; [Aspirin co-treated with Hydrochloric Acid] results in increased expression of PTGS2 protein; Aspirin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 mRNA]; Aspirin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 protein]PMID:15236176 PMID:21513785
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