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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731002
Species: Homo sapiens
RGD Object: Gene
Symbol: CASP3
Name: caspase 3
Acc ID: CHEBI:76451
Term: alloxan
Definition: A member of the class of pyrimidones, the structure of which is that of perhydropyrimidine substituted at C-2, -4, -5 and -6 by oxo groups.
Chemical ID: MESH:D000496
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CASP3increases activityISOCasp3 (Rattus norvegicus)6480464CTDAlloxan results in increased activity of CASP3 proteinPMID:21982801
CASP3increases expressionISOCasp3 (Rattus norvegicus)6480464CTDAlloxan results in increased expression of CASP3 protein modified formPMID:22138235 PMID:23092809
CASP3multiple interactionsISOCasp3 (Rattus norvegicus)6480464CTDD-Glucaric acid, 1,4-lactone inhibits the reaction [Alloxan results in increased activity of CASP3 protein]; Taurine inhibits the reaction [Alloxan results in increased expression of CASP3 protein modified form]PMID:21982801 PMID:22138235 PMID:23092809
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