GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | CASP3 | increases activity | EXP | | 6480464 | CTD | Tretinoin results in increased activity of CASP3 protein | PMID:12431242 PMID:14519626 PMID:16168621 PMID:16196285 PMID:16411021 PMID:16568081 PMID:16765349 PMID:17701358 PMID:17915318 PMID:21159206 | CASP3 | increases cleavage | EXP | | 6480464 | CTD | Tretinoin results in increased cleavage of CASP3 protein | PMID:15703382 PMID:16135400 PMID:16935849 | CASP3 | increases expression | EXP | | 6480464 | CTD | Tretinoin results in increased expression of CASP3; Tretinoin results in increased expression of CASP3 protein | PMID:16109544 PMID:16157052 PMID:16909596 | CASP3 | multiple interactions | EXP | | 6480464 | CTD | [alpha-Tocopherol co-treated with Tretinoin] results in increased activity of CASP3 protein; [IDH1 protein affects the susceptibility to Tretinoin] which affects the cleavage of CASP3 protein; [IFNB1 protein co-treated with Tretinoin] results in increased cleavage of and results in increased activity of CASP3 protein; [Tretinoin co-treated with ALK gene mutant form] results in increased cleavage of CASP3 protein; [Tretinoin co-treated with IFNG protein] results in increased activity of CASP3 protein; [Tretinoin co-treated with Paclitaxel] results in increased activity of CASP3 protein; [Tretinoin co-treated with Zoledronic Acid] results in increased activity of CASP3 protein; CYP26A1 protein inhibits the reaction [Tretinoin results in increased cleavage of CASP3 protein]; LTF protein inhibits the reaction [Tretinoin results in increased activity of CASP3 protein]; MGAT5 protein inhibits the reaction [Tretinoin results in increased activity of CASP3 protein]; RARA gene mutant form inhibits the reaction [Tretinoin promotes the reaction [Arsenic Trioxide results in increased activity of CASP3 protein]]; TGFB1 protein inhibits the reaction [Tretinoin results in increased cleavage of and results in increased activity of CASP3 protein]; Tretinoin inhibits the reaction [perfluorooctanoic acid results in increased cleavage of CASP3 protein]; Tretinoin promotes the reaction [[GJB1 protein co-treated with GJB2 protein] promotes the reaction [Cisplatin results in increased activity of CASP3 protein]]; Tretinoin promotes the reaction [Arsenic Trioxide results in increased activity of CASP3 protein]; Tretinoin promotes the reaction [Imatinib Mesylate results in increased activity of CASP3 protein]; Tretinoin promotes the reaction [Rosiglitazone results in increased activity of CASP3 protein]; Tretinoin results in increased cleavage of and results in increased activity of CASP3 protein; Tretinoin results in increased expression of and results in increased cleavage of CASP3 protein | PMID:15703382 PMID:16168621 PMID:16242776 PMID:16411021 PMID:16826196 PMID:16947022 PMID:17701358 PMID:17874176 PMID:17915318 PMID:17960384 PMID:19467017 PMID:19731824 PMID:20349282 PMID:20576349 PMID:23747833 PMID:23830798 PMID:25003661 PMID:26951332 PMID:32971237 | CASP3 | decreases expression | ISO | Casp3 (Mus musculus) | 6480464 | CTD | Tretinoin results in decreased expression of CASP3 mRNA | PMID:22498432 | CASP3 | increases activity | ISO | Casp3 (Mus musculus) | 6480464 | CTD | Tretinoin results in increased activity of CASP3 protein | PMID:16291826 PMID:16712891 PMID:18668354 | CASP3 | increases cleavage | ISO | Casp3 (Mus musculus) | 6480464 | CTD | Tretinoin results in increased cleavage of CASP3 protein | PMID:21626648 PMID:29767511 | CASP3 | increases expression | ISO | Casp3 (Mus musculus) | 6480464 | CTD | Tretinoin results in increased expression of CASP3 protein | PMID:11851873 PMID:16764683 PMID:33823233 | CASP3 | multiple interactions | ISO | Casp3 (Mus musculus) | 6480464 | CTD | 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Tretinoin results in increased activity of CASP3 protein]; [Tretinoin co-treated with U 0126] results in increased cleavage of CASP3 protein; benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [Tretinoin results in increased activity of CASP3 protein]; MAPT protein promotes the reaction [Tretinoin results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [Tretinoin results in increased activity of CASP3 protein]; Tretinoin promotes the reaction [arsenic trioxide results in increased activity of CASP3 protein]; Tretinoin promotes the reaction [pevonedistat results in increased cleavage of and results in increased activity of CASP3 protein]; Tretinoin promotes the reaction [Tretinoin results in increased activity of CASP3 protein] | PMID:15688020 PMID:16291826 PMID:16417947 PMID:16712891 PMID:17026715 PMID:22110742 | CASP3 | multiple interactions | ISO | Casp3 (Rattus norvegicus) | 6480464 | CTD | [Quercetin co-treated with Tretinoin] results in increased cleavage of CASP3 protein; DDAH2 protein promotes the reaction [Tretinoin inhibits the reaction [cobaltous chloride results in increased activity of CASP3 protein]]; Tretinoin inhibits the reaction [cobaltous chloride results in increased activity of CASP3 protein]; Tretinoin inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein] | PMID:19156866 PMID:25203460 PMID:26915917 | | ||||||||||||||||||||||
| Go Back to source page | Continue to Ontology report |