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GENE - TERM ANNOTATION REPORT

RGD ID: 730981
Species: Homo sapiens
RGD Object: Gene
Symbol: IL1B
Name: interleukin 1 beta
Acc ID: DOID:1184
Term: nephrotic syndrome
Definition: A nephrosis characterized by marked increase in glomerular protein permeability resulting in marked elevation of urine protein levels, hypoalbuminemia, hyperlipidemia, and hypercoagulability. (DO)
Definition Source(s): https://en.wikipedia.org/wiki/Nephrotic_syndrome "DO" "DO", https://www.niddk.nih.gov/health-information/kidney-disease/nephrotic-syndrome-adults "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
IL1BseverityIAGP 7175337RGDassociated with Purpura, Schoenlein-Henoch; DNA:snp:promoter:g.-511C>T (human) 
IL1B IEP 7175339RGDprotein:increased expression:serum (human) 
IL1B ISOIl1b (Rattus norvegicus)7175324RGD  
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