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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730972
Species: Homo sapiens
RGD Object: Gene
Symbol: SREBF2
Name: sterol regulatory element binding transcription factor 2
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SREBF2affects expressionISOSrebf2 (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of SREBF2 mRNAPMID:21570461 PMID:24058054
SREBF2decreases expressionISOSrebf2 (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of SREBF2 mRNAPMID:21215274 PMID:32109520 PMID:33387578
SREBF2decreases expressionISOSrebf2 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of SREBF2 mRNAPMID:20005886 PMID:21851831 PMID:28238261
SREBF2multiple interactionsISOSrebf2 (Mus musculus)6480464CTDTetrachlorodibenzodioxin inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in decreased expression of SREBF2 mRNA]PMID:21851831
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