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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730951
Species: Homo sapiens
RGD Object: Gene
Symbol: NOS2
Name: nitric oxide synthase 2
Acc ID: CHEBI:66359
Term: (+)-alpha-viniferin
Definition: A nine-membered macrocycle that incorporates three 6-hydroxy-2-(4-hydroxyphenyl)-2,3-dihydro-1-benzofuranyl moieties as part of the cyclic skeleton. It is isolated from Caragana chamlague Lamarck and exhibits significant inhibitory effect towards the enzyme acetylcholinesterase (EC 3.1.1.7).
Chemical ID: MESH:C064176
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NOS2multiple interactionsISONos2 (Mus musculus)6480464CTDalpha-viniferin inhibits the reaction [IFNG protein results in increased expression of NOS2 mRNA]; alpha-viniferin inhibits the reaction [IFNG protein results in increased expression of NOS2 protein]; alpha-viniferin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; alpha-viniferin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]PMID:14531020 PMID:20424383 PMID:24859013
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