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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730951
Species: Homo sapiens
RGD Object: Gene
Symbol: NOS2
Name: nitric oxide synthase 2
Acc ID: CHEBI:46345
Term: 5-fluorouracil
Definition: A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Chemical ID: MESH:D005472
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NOS2increases expressionEXP 6480464CTDFluorouracil results in increased expression of NOS2 proteinPMID:12150722
NOS2multiple interactionsISONos2 (Mus musculus)6480464CTDFluorouracil inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; Fluorouracil inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; Fluorouracil results in increased expression of and results in increased activity of NOS2 proteinPMID:16724238 PMID:18069768
NOS2multiple interactionsISONos2 (Rattus norvegicus)6480464CTDFluorouracil inhibits the reaction [Diethylnitrosamine results in increased expression of NOS2 mRNA]PMID:31129132
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