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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730951
Species: Homo sapiens
RGD Object: Gene
Symbol: NOS2
Name: nitric oxide synthase 2
Acc ID: CHEBI:17823
Term: calcitriol
Definition: A hydroxycalciol that is calcidiol in which the pro-S hydrogen of calcidiol is replaced by a hydroxy group. It is the active form of vitamin D3, produced fom calciol via hydoxylation in the liver to form calcidiol, which is subsequently oxidised in the kidney to give calcitriol.
Chemical ID: MESH:D002117
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NOS2decreases expressionISONos2 (Mus musculus)6480464CTDCalcitriol results in decreased expression of NOS2 proteinPMID:17600374
NOS2multiple interactionsISONos2 (Rattus norvegicus)6480464CTD[Maxepa co-treated with Calcitriol] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of NOS2 mRNA]PMID:20599847
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