GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | NOS2 | increases expression | EXP | | 6480464 | CTD | Glucose results in increased expression of NOS2 mRNA; Glucose results in increased expression of NOS2 protein | PMID:22363694 PMID:32942007 | NOS2 | multiple interactions | EXP | | 6480464 | CTD | SOD1 protein inhibits the reaction [Glucose results in increased expression of NOS2 mRNA]; SOD1 protein inhibits the reaction [Glucose results in increased expression of NOS2 protein] | PMID:22425406 | NOS2 | increases expression | ISO | Nos2 (Mus musculus) | 6480464 | CTD | Glucose results in increased expression of NOS2 mRNA; Glucose results in increased expression of NOS2 protein | PMID:22425406 PMID:30076216 PMID:33631230 | NOS2 | increases expression | ISO | Nos2 (Rattus norvegicus) | 6480464 | CTD | Glucose results in increased expression of NOS2 mRNA; Glucose results in increased expression of NOS2 protein | PMID:19587355 PMID:23770986 | NOS2 | multiple interactions | ISO | Nos2 (Mus musculus) | 6480464 | CTD | 3-((6-(2-methoxyphenyl)pyrimidin-4-yl)amino)phenyl)methane sulfonamide inhibits the reaction [Glucose results in increased expression of NOS2 mRNA]; [Glucose co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of NOS2 protein; [Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of NOS2 protein; CDK9 protein affects the reaction [Glucose results in increased expression of NOS2 mRNA]; Prodigiosin inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of NOS2 protein]; prolinedithiocarbamate inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of NOS2 protein]; Silymarin inhibits the reaction [[Glucose co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of NOS2 protein] | PMID:21925195 PMID:29753610 PMID:33631230 | NOS2 | multiple interactions | ISO | Nos2 (Rattus norvegicus) | 6480464 | CTD | [Glucose co-treated with IGF2R protein modified form] results in decreased expression of NOS2 protein; [Linoleic Acid co-treated with Glucose] affects the reaction [Azoxymethane affects the expression of NOS2 protein]; [Oxygen co-treated with Glucose] promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of NOS2 protein]; [Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of NOS2 protein; PRKCB protein affects the reaction [Glucose results in increased expression of NOS2 protein]; Quercetin inhibits the reaction [Glucose results in increased expression of NOS2 mRNA]; Quercetin inhibits the reaction [Glucose results in increased expression of NOS2 protein]; ruboxistaurin inhibits the reaction [Glucose results in increased expression of NOS2 protein] | PMID:19587355 PMID:22467055 PMID:23061969 PMID:23770986 PMID:36462176 | | ||||||||||||||||||||||
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