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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730947
Species: Mus musculus
RGD Object: Gene
Symbol: Crh
Name: corticotropin releasing hormone
Acc ID: CHEBI:78734
Term: tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate
Definition: A tropane alkaloid that is (1R,5)-8-methyl-8-azabicyclo[3.2.1]octane substituted by a (3-hydroxy-2-phenylpropanoyl)oxy group at position 3.
Chemical ID: MESH:D001285
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Crhmultiple interactionsISOCrh (Rattus norvegicus)6480464CTDAtropine inhibits the reaction [acephate results in increased expression of CRH mRNA]; Atropine inhibits the reaction [acephate results in increased secretion of CRH protein]; Atropine inhibits the reaction [methamidophos results in increased expression of CRH mRNA]; Atropine inhibits the reaction [methamidophos results in increased secretion of CRH protein]PMID:12039681
Crhmultiple interactionsISOCRH (Homo sapiens)6480464CTD[Atropine co-treated with SR 140333 co-treated with SR 48968] results in decreased activity of CRH proteinPMID:12906840
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