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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730945
Species: Mus musculus
RGD Object: Gene
Symbol: Abcb11
Name: ATP-binding cassette, sub-family B member 11
Acc ID: CHEBI:9753
Term: troglitazone
Definition: A chromane that has formula C24H27NO5S.
Chemical ID: MESH:C057693
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcb11decreases activityISOAbcb11 (Rattus norvegicus)6480464CTDtroglitazone results in decreased activity of ABCB11 proteinPMID:15465654 PMID:15509663 PMID:20147439 PMID:29146462
Abcb11decreases activityISOABCB11 (Homo sapiens)6480464CTDtroglitazone results in decreased activity of ABCB11 proteinPMID:20147439 PMID:20829430 PMID:22646477 PMID:23956101 PMID:24014644 PMID:28437613
Abcb11decreases expressionISOAbcb11 (Rattus norvegicus)6480464CTDtroglitazone results in decreased expression of ABCB11 mRNAPMID:27765674
Abcb11decreases expressionISOABCB11 (Homo sapiens)6480464CTDtroglitazone results in decreased expression of ABCB11PMID:22673116
Abcb11multiple interactionsISOAbcb11 (Rattus norvegicus)6480464CTD[troglitazone results in decreased activity of ABCB11 protein] which results in decreased export of Taurodeoxycholic Acid; [troglitazone results in decreased activity of ABCB11 protein] which results in decreased secretion of Rosuvastatin Calcium; troglitazone binds to and results in decreased activity of ABCB11 protein; troglitazone inhibits the reaction [ABCB11 protein results in increased export of Bile Acids and Salts]; troglitazone inhibits the reaction [ABCB11 protein results in increased export of Taurocholic Acid]PMID:11179459 PMID:11557132 PMID:19853032 PMID:20147439 PMID:29146462
Abcb11multiple interactionsISOABCB11 (Homo sapiens)6480464CTD[Troglitazone results in decreased activity of ABCB11 protein] which results in decreased export of Taurodeoxycholic Acid; Enzymes and Coenzymes promotes the reaction [Troglitazone inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]]; Troglitazone inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]; Troglitazone inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]PMID:20147439 PMID:24014644 PMID:35101544
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