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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730945
Species: Mus musculus
RGD Object: Gene
Symbol: Abcb11
Name: ATP-binding cassette, sub-family B member 11
Acc ID: CHEBI:47519
Term: ketoconazole
Definition: A racemate consisting of equimolar amounts of (2R,4S)- and (2S,4R)-ketoconazole.
Chemical ID: MESH:D007654
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcb11decreases activityISOABCB11 (Homo sapiens)6480464CTDKetoconazole results in decreased activity of ABCB11 proteinPMID:20147439 PMID:20829430 PMID:23956101 PMID:24014644 PMID:28437613
Abcb11multiple interactionsISOABCB11 (Homo sapiens)6480464CTD[Ketoconazole results in decreased activity of ABCB11 protein] which results in decreased export of Taurodeoxycholic Acid; Ketoconazole inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]PMID:20147439 PMID:24014644
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