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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730944
Species: Homo sapiens
RGD Object: Gene
Symbol: ABCB11
Name: ATP binding cassette subfamily B member 11
Acc ID: CHEBI:28077
Term: rifampicin
Definition: A member of the class of rifamycins that is a a semisynthetic antibiotic derived from Amycolatopsis rifamycinica (previously known as Amycolatopsis mediterranei and Streptomyces mediterranei).
Chemical ID: MESH:D012293
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ABCB11decreases activityEXP 6480464CTDRifampin results in decreased activity of ABCB11 proteinPMID:20829430 PMID:24014644 PMID:28437613
ABCB11decreases expressionEXP 6480464CTDRifampin results in decreased expression of ABCB11 mRNAPMID:16837569
ABCB11multiple interactionsEXP 6480464CTD[Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] affects the expression of ABCB11 protein; Rifampin inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]PMID:24014644 PMID:35835356
ABCB11decreases expressionISOAbcb11 (Rattus norvegicus)6480464CTDRifampin results in decreased expression of ABCB11 mRNA; Rifampin results in decreased expression of ABCB11 proteinPMID:12135489 PMID:35544702
ABCB11decreases expressionISOAbcb11 (Mus musculus)6480464CTDRifampin results in decreased expression of ABCB11 proteinPMID:25886055
ABCB11multiple interactionsISOAbcb11 (Rattus norvegicus)6480464CTDtanshinone inhibits the reaction [Rifampin results in decreased expression of ABCB11 mRNA]; tanshinone inhibits the reaction [Rifampin results in decreased expression of ABCB11 protein]PMID:35544702
ABCB11multiple interactionsISOAbcb11 (Mus musculus)6480464CTD[Rifampin co-treated with Isoniazid] results in decreased expression of ABCB11 proteinPMID:25886055
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