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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730935
Species: Homo sapiens
RGD Object: Gene
Symbol: HIF1A
Name: hypoxia inducible factor 1 subunit alpha
Acc ID: CHEBI:30621
Term: diarsenic trioxide
Definition: An arsenic oxide in which arsenic and oxygen atoms are present in the ratio 2:3.
Chemical ID: MESH:C006632
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
HIF1Aaffects expressionEXP 6480464CTDArsenic Trioxide affects the expression of HIF1A mRNAPMID:20458559
HIF1Adecreases expressionEXP 6480464CTDArsenic Trioxide results in decreased expression of HIF1A; Arsenic Trioxide results in decreased expression of HIF1A mRNA; Arsenic Trioxide results in decreased expression of HIF1A proteinPMID:19769630 PMID:25047463 PMID:25088040 PMID:34108876
HIF1Aincreases expressionEXP 6480464CTDArsenic Trioxide results in increased expression of HIF1A proteinPMID:12482858 PMID:29396848
HIF1Amultiple interactionsEXP 6480464CTD[Oxygen deficiency co-treated with Arsenic Trioxide] results in increased expression of HIF1A protein; Arsenic Trioxide promotes the reaction [cobaltous chloride results in increased expression of HIF1A protein]; Arsenic Trioxide promotes the reaction [Deferoxamine results in increased expression of HIF1A protein]PMID:16330433 PMID:19825857
HIF1Aincreases expressionISOHif1a (Mus musculus)6480464CTDArsenic Trioxide results in increased expression of HIF1A proteinPMID:15888669
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