GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | HIF1A | increases activity | EXP | | 6480464 | CTD | Copper results in increased activity of HIF1A protein | PMID:17339407 | HIF1A | multiple interactions | EXP | | 6480464 | CTD | [Chelating Agents binds to Copper] which results in decreased expression of HIF1A mRNA; [Copper results in increased activity of HIF1A protein] which results in increased expression of VEGFA protein; [Zinc co-treated with Copper] inhibits the reaction [Clioquinol results in increased expression of HIF1A protein]; CCS protein promotes the reaction [[Copper results in increased activity of HIF1A protein] which results in increased expression of VEGFA protein]; CCS protein promotes the reaction [Copper results in increased activity of HIF1A protein] | PMID:16973622 PMID:17339407 PMID:30911355 | HIF1A | multiple interactions | ISO | Hif1a (Rattus norvegicus) | 6480464 | CTD | [Copper deficiency co-treated with tetrathiomolybdate] inhibits the reaction [EP300 protein binds to HIF1A protein]; [Copper deficiency co-treated with tetrathiomolybdate] results in decreased expression of HIF1A protein | PMID:22276220 | | ||||||||||||||||||||||
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