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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730935
Species: Homo sapiens
RGD Object: Gene
Symbol: HIF1A
Name: hypoxia inducible factor 1 subunit alpha
Acc ID: CHEBI:29063
Term: L-mimosine
Definition: An L-alpha-amino acid that is propionic acid substituted by an amino group at position 2 and a 3-hydroxy-4-oxopyridin-1(4H)-yl group at position 3 (the 2S-stereoisomer). It a non-protein plant amino acid isolated from Mimosa pudica.
Chemical ID: MESH:D008898
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
HIF1Aincreases expressionEXP 6480464CTDMimosine results in increased expression of HIF1A proteinPMID:24349381
HIF1Aincreases activityISOHif1a (Rattus norvegicus)6480464CTDMimosine results in increased activity of HIF1A proteinPMID:10559391
HIF1Aincreases expressionISOHif1a (Rattus norvegicus)6480464CTDMimosine results in increased expression of HIF1A proteinPMID:25469848
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