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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730935
Species: Homo sapiens
RGD Object: Gene
Symbol: HIF1A
Name: hypoxia inducible factor 1 subunit alpha
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
HIF1Aaffects expressionEXP 6480464CTDresveratrol affects the expression of HIF1A proteinPMID:17473185
HIF1Adecreases expressionEXP 6480464CTDresveratrol results in decreased expression of HIF1A; resveratrol results in decreased expression of HIF1A mRNA; resveratrol results in decreased expression of HIF1A proteinPMID:12002526 PMID:15297429 PMID:19828106 PMID:23314035
HIF1Aincreases degradationEXP 6480464CTDresveratrol results in increased degradation of HIF1A proteinPMID:15297429 PMID:17919812
HIF1Aincreases expressionEXP 6480464CTDresveratrol results in increased expression of HIF1A proteinPMID:22245592
HIF1Amultiple interactionsEXP 6480464CTD[Resveratrol results in increased activity of SIRT1 protein] which results in increased expression of HIF1A protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Resveratrol inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]]; Resveratrol inhibits the reaction [2,2'-Dipyridyl results in increased expression of HIF1A protein]; Resveratrol inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Oxygen deficiency results in increased expression of HIF1A protein]]; Resveratrol inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein]; Resveratrol inhibits the reaction [Dinoprostone results in increased expression of and results in increased acetylation of HIF1A protein]; Resveratrol inhibits the reaction [HIF1A protein results in increased activity of AR protein]; Resveratrol inhibits the reaction [IGF1 protein results in increased expression of HIF1A protein]; Resveratrol inhibits the reaction [INS protein results in increased expression of HIF1A protein]; Resveratrol inhibits the reaction [lysophosphatidic acid results in increased expression of HIF1A protein]; Resveratrol inhibits the reaction [Oxygen deficiency affects the localization of HIF1A protein]; Resveratrol inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]; Resveratrol results in decreased expression of and affects the localization of HIF1A protein; Resveratrol results in increased ubiquitination of and results in increased degradation of HIF1A protein; SIRT1 protein promotes the reaction [Resveratrol inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein]]PMID:15297429 PMID:16227395 PMID:17919812 PMID:18674879 PMID:20153296 PMID:22245592 PMID:24975222 PMID:25297617 PMID:25815440 PMID:26174951 PMID:30409902
HIF1Adecreases expressionISOHif1a (Rattus norvegicus)6480464CTDresveratrol results in decreased expression of HIF1A proteinPMID:22050707
HIF1Adecreases expressionISOHif1a (Mus musculus)6480464CTDresveratrol results in decreased expression of HIF1A proteinPMID:24221993
HIF1Amultiple interactionsISOHif1a (Rattus norvegicus)6480464CTD[resveratrol co-treated with plastochromanol 8] results in decreased expression of HIF1A protein; resveratrol inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency co-treated with Oxygen] results in increased expression of HIF1A mRNA]; resveratrol inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency co-treated with Oxygen] results in increased expression of HIF1A protein]; resveratrol inhibits the reaction [Glucose results in increased expression of HIF1A mRNA]; resveratrol inhibits the reaction [Glucose results in increased expression of HIF1A protein]; resveratrol inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A mRNA]; SIRT1 protein affects the reaction [resveratrol inhibits the reaction [Glucose results in increased expression of HIF1A protein]]PMID:21914476 PMID:22050707 PMID:23421680 PMID:26891083
HIF1Amultiple interactionsISOHif1a (Mus musculus)6480464CTDbenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [resveratrol results in decreased expression of HIF1A protein]; resveratrol inhibits the reaction [Dextran Sulfate results in increased expression of HIF1A protein]; resveratrol inhibits the reaction [Nicotine results in decreased expression of HIF1A mRNA]PMID:22687363 PMID:24221993 PMID:26074695
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