GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | HIF1A | multiple interactions | EXP | | 6480464 | CTD | [Dinoprostone binds to and results in increased activity of PTGER1 protein] which results in increased expression of HIF1A protein; [nickel sulfate co-treated with Dinoprostone] results in increased expression of HIF1A protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [[Dinoprostone binds to and results in increased activity of PTGER1 protein] which results in increased expression of HIF1A protein]; Dinoprostone promotes the reaction [HIF1A protein binds to EP300 protein]; Dinoprostone promotes the reaction [nickel sulfate results in increased expression of and results in increased activity of HIF1A protein]; Dinoprostone results in increased expression of and results in increased acetylation of HIF1A protein; HIF1A protein promotes the reaction [[nickel sulfate co-treated with Dinoprostone] results in increased secretion of CXCL8 protein]; HIF1A protein promotes the reaction [[Oxygen deficiency results in increased expression of PTGES protein] which results in increased chemical synthesis of Dinoprostone]; KAT2B protein affects the reaction [Dinoprostone promotes the reaction [HIF1A protein binds to EP300 protein]]; KAT2B protein affects the reaction [Dinoprostone results in increased expression of and results in increased acetylation of HIF1A protein]; Pertussis Toxin inhibits the reaction [[Dinoprostone binds to and results in increased activity of PTGER1 protein] which results in increased expression of HIF1A protein]; Resveratrol inhibits the reaction [Dinoprostone results in increased expression of and results in increased acetylation of HIF1A protein]; SB 203580 inhibits the reaction [[nickel sulfate co-treated with Dinoprostone] results in increased expression of HIF1A protein]; Sirolimus inhibits the reaction [[Dinoprostone binds to and results in increased activity of PTGER1 protein] which results in increased expression of HIF1A protein]; SIRT1 protein inhibits the reaction [Dinoprostone promotes the reaction [HIF1A protein binds to EP300 protein]]; SIRT1 protein inhibits the reaction [Dinoprostone results in increased expression of and results in increased acetylation of HIF1A protein]; Wortmannin inhibits the reaction [[Dinoprostone binds to and results in increased activity of PTGER1 protein] which results in increased expression of HIF1A protein] | PMID:18832182 PMID:20042640 PMID:20335389 PMID:23526216 PMID:30409902 | HIF1A | multiple interactions | ISO | Hif1a (Mus musculus) | 6480464 | CTD | [HIF1A protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of CCN2 mRNA]; [HIF1A protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFB1 mRNA]; [HIF1A protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFB2 mRNA]; [HIF1A protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFBR1 mRNA]; [HIF1A protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFBR2 mRNA]; Dinoprostone inhibits the reaction [Bleomycin results in increased expression of HIF1A mRNA]; HIF1A protein affects the reaction [Dinoprostone inhibits the reaction [Bleomycin results in increased expression of TGFB3 mRNA]] | PMID:28434932 | | ||||||||||||||||||||||
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