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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730935
Species: Homo sapiens
RGD Object: Gene
Symbol: HIF1A
Name: hypoxia inducible factor 1 subunit alpha
Acc ID: CHEBI:144421
Term: iron(III) citrate
Definition: An iron chelate resulting from the combination of iron(3+) and citrate(3-).
Chemical ID: MESH:C025314
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
HIF1Amultiple interactionsEXP 6480464CTDferric citrate inhibits the reaction [Deferoxamine results in increased expression of HIF1A protein]; ferric citrate inhibits the reaction [Quercetin results in increased expression of HIF1A mRNA]; ferric citrate inhibits the reaction [Quercetin results in increased expression of HIF1A protein]PMID:16527254 PMID:17015263 PMID:17364964
HIF1Amultiple interactionsISOHif1a (Mus musculus)6480464CTDferric citrate inhibits the reaction [Deferoxamine results in increased expression of HIF1A protein]PMID:16527254
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