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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730927
Species: Homo sapiens
RGD Object: Gene
Symbol: IL5
Name: interleukin 5
Acc ID: CHEBI:4031
Term: cyclosporin A
Definition: A cyclic nonribosomal peptide of eleven amino acids; an immunosuppressant drug widely used in post-allogeneic organ transplant to reduce the activity of the patient's immune system, and therefore the risk of organ rejection. Also causes reversible inhibition of immunocompetent lymphocytes in the G0- and G1-phase of the cell cycle.
Chemical ID: MESH:D016572
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
IL5decreases expressionEXP 6480464CTDCyclosporine results in decreased expression of IL5 proteinPMID:7540862
IL5multiple interactionsEXP 6480464CTDCyclosporine inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL5 protein]; Cyclosporine inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL5 mRNA]; Cyclosporine inhibits the reaction [nickel sulfate results in increased secretion of IL5 protein]PMID:1371491 PMID:15663561 PMID:17475810
IL5decreases expressionISOIl5 (Mus musculus)6480464CTDCyclosporine results in decreased expression of IL5 proteinPMID:7988651
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