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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730924
Species: Mus musculus
RGD Object: Gene
Symbol: E2f1
Name: E2F transcription factor 1
Acc ID: CHEBI:27656
Term: camptothecin
Definition: A pyranoindolizinoquinoline that is pyrano[3',4':6,7]indolizino[1,2-b]quinoline which is substituted by oxo groups at positions 3 and 14, and by an ethyl group and a hydroxy group at position 4 (the S enantiomer).
Chemical ID: MESH:D002166
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
E2f1increases expressionEXP 6480464CTDCamptothecin results in increased expression of E2F1 mRNAPMID:22403396
E2f1multiple interactionsEXP 6480464CTD7-hydroxystaurosporine inhibits the reaction [Camptothecin results in increased expression of E2F1 mRNA]; Caffeine inhibits the reaction [Camptothecin results in increased expression of E2F1 mRNA]; E2F1 protein promotes the reaction [Camptothecin results in increased expression of RRM2 protein]PMID:22403396
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