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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730901
Species: Homo sapiens
RGD Object: Gene
Symbol: HMOX1
Name: heme oxygenase 1
Acc ID: CHEBI:3139
Term: bleomycin A2
Definition: A bleomycin that has formula C55H84N17O21S3.
Chemical ID: MESH:D001761
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
HMOX1decreases expressionISOHmox1 (Rattus norvegicus)6480464CTDBleomycin results in decreased expression of HMOX1 proteinPMID:26768587
HMOX1increases expressionISOHmox1 (Mus musculus)6480464CTDBleomycin results in increased expression of HMOX1 proteinPMID:16317386
HMOX1increases expressionISOHmox1 (Rattus norvegicus)6480464CTDBleomycin results in increased expression of HMOX1 mRNAPMID:26093215
HMOX1multiple interactionsISOHmox1 (Mus musculus)6480464CTDPPARA protein affects the reaction [Bleomycin results in increased expression of HMOX1 protein]PMID:16317386
HMOX1multiple interactionsISOHmox1 (Rattus norvegicus)6480464CTDcelastrol inhibits the reaction [Bleomycin results in decreased expression of HMOX1 protein]; Methylprednisolone inhibits the reaction [Bleomycin results in increased expression of HMOX1 mRNA]; Phytochemicals inhibits the reaction [Bleomycin results in increased expression of HMOX1 mRNA]PMID:26093215 PMID:26768587
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