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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730901
Species: Homo sapiens
RGD Object: Gene
Symbol: HMOX1
Name: heme oxygenase 1
Acc ID: CHEBI:31206
Term: ammonium chloride
Definition: An inorganic chloride having ammonium as the counterion.
Chemical ID: MESH:D000643
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
HMOX1increases expressionEXP 6480464CTDAmmonium Chloride results in increased expression of HMOX1 mRNAPMID:27867098
HMOX1multiple interactionsEXP 6480464CTDAcetylcysteine inhibits the reaction [Ammonium Chloride results in increased expression of HMOX1 protein]; Ammonium Chloride results in increased expression of and results in increased activity of HMOX1 protein; Dactinomycin inhibits the reaction [Ammonium Chloride results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [Ammonium Chloride results in increased expression of HMOX1 mRNA]; Rotenone inhibits the reaction [Ammonium Chloride results in increased expression of HMOX1 protein]PMID:27867098
HMOX1affects expressionISOHmox1 (Rattus norvegicus)6480464CTDAmmonium Chloride affects the expression of HMOX1 mRNAPMID:16483693
HMOX1increases expressionISOHmox1 (Mus musculus)6480464CTDAmmonium Chloride results in increased expression of HMOX1 proteinPMID:27867098
HMOX1increases expressionISOHmox1 (Rattus norvegicus)6480464CTDAmmonium Chloride results in increased expression of HMOX1 mRNA; Ammonium Chloride results in increased expression of HMOX1 proteinPMID:12420312
HMOX1multiple interactionsISOHmox1 (Rattus norvegicus)6480464CTDMelatonin inhibits the reaction [Ammonium Chloride results in increased expression of HMOX1 mRNA]; Taurine inhibits the reaction [Ammonium Chloride results in increased expression of HMOX1 mRNA]; TLR5 gene mutant form inhibits the reaction [Ammonium Chloride results in increased expression of HMOX1 mRNA]PMID:12420312 PMID:30508503
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