GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | HMOX1 | increases activity | EXP | | 6480464 | CTD | Cadmium results in increased activity of HMOX1 protein | PMID:21172416 | HMOX1 | increases expression | EXP | | 6480464 | CTD | Cadmium results in increased expression of HMOX1 mRNA; Cadmium results in increased expression of HMOX1 protein | PMID:10349844 PMID:12716893 PMID:12783778 PMID:14647439 PMID:15242350 PMID:16020198 PMID:16816389 PMID:16959797 PMID:17156779 PMID:17204476 PMID:17244614 PMID:17547211 PMID:21120746 PMID:21172416 PMID:23794209 PMID:24284285 PMID:26600472 PMID:27005776 PMID:8077238 | HMOX1 | multiple interactions | EXP | | 6480464 | CTD | 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Cadmium results in increased expression of HMOX1 protein]; [Cadmium analog co-treated with Selenium analog co-treated with zinc sulfide analog] affects the expression of HMOX1 mRNA; [Cadmium analog co-treated with Selenium analog co-treated with zinc sulfide analog] results in increased expression of HMOX1 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of HMOX1 mRNA; [Water Pollutants, Chemical co-treated with Cadmium] results in increased expression of HMOX1 mRNA; Acetylcysteine inhibits the reaction [Cadmium results in increased expression of HMOX1 protein]; Cadmium promotes the reaction [HSF1 protein binds to HMOX1 promoter]; diacetyldichlorofluorescein inhibits the reaction [Cadmium results in increased expression of HMOX1 mRNA]; diacetyldichlorofluorescein inhibits the reaction [Cadmium results in increased expression of HMOX1 protein]; IFNG protein inhibits the reaction [Cadmium results in increased expression of HMOX1 mRNA]; SB 203580 inhibits the reaction [Cadmium results in increased expression of HMOX1 protein] | PMID:10349844 PMID:14647439 PMID:16959797 PMID:17244614 PMID:21481475 PMID:26472158 PMID:29741670 PMID:31738976 PMID:32645461 | HMOX1 | affects expression | ISO | Hmox1 (Rattus norvegicus) | 6480464 | CTD | Cadmium affects the expression of HMOX1 mRNA | PMID:16948784 | HMOX1 | decreases expression | ISO | Hmox1 (Mus musculus) | 6480464 | CTD | Cadmium results in decreased expression of HMOX1 mRNA | PMID:37270049 | HMOX1 | increases expression | ISO | Hmox1 (Mus musculus) | 6480464 | CTD | Cadmium results in increased expression of HMOX1 mRNA; Cadmium results in increased expression of HMOX1 protein | PMID:10473555 PMID:10733587 PMID:14658758 PMID:15010501 PMID:15337587 PMID:16183037 PMID:16487038 PMID:16517059 PMID:24067728 PMID:26363317 PMID:29111403 | HMOX1 | increases expression | ISO | Hmox1 (Rattus norvegicus) | 6480464 | CTD | Cadmium results in increased expression of HMOX1; Cadmium results in increased expression of HMOX1 mRNA; Cadmium results in increased expression of HMOX1 protein | PMID:12890491 PMID:12974610 PMID:22008531 PMID:27658547 PMID:2912370 PMID:8760880 | HMOX1 | multiple interactions | ISO | Hmox1 (Mus musculus) | 6480464 | CTD | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of HMOX1 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of HMOX1 protein; Acetylcysteine inhibits the reaction [Cadmium results in increased expression of HMOX1 protein]; Ascorbic Acid inhibits the reaction [Cadmium results in increased expression of HMOX1 mRNA]; Cadmium inhibits the reaction [BACH1 protein results in decreased expression of HMOX1 mRNA]; Cadmium promotes the reaction [HMOX1 protein binds to CAV1 protein]; Cadmium promotes the reaction [HMOX1 protein binds to CAV2 protein]; Cadmium results in increased expression of and results in increased activity of HMOX1 protein; CTH protein affects the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of HMOX1 protein]; NFE2L2 gene mutant form inhibits the reaction [Cadmium results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of HMOX1 mRNA]; NFE2L2 protein affects the reaction [Cadmium results in increased expression of HMOX1 mRNA]; O(2)-vinyl-1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate inhibits the reaction [Cadmium results in increased expression of HMOX1 mRNA] | PMID:10473555 PMID:14504288 PMID:14658758 PMID:15010501 PMID:16183037 PMID:16517059 PMID:18512965 PMID:29111403 PMID:31166132 PMID:31614173 PMID:32645461 PMID:33398418 | HMOX1 | multiple interactions | ISO | Hmox1 (Rattus norvegicus) | 6480464 | CTD | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of HMOX1 protein; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of HMOX1 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of HMOX1 protein; [Cadmium co-treated with bergenin] results in increased expression of HMOX1 protein; [Cadmium co-treated with galangin] results in increased expression of HMOX1 protein; Acetylcysteine inhibits the reaction [Cadmium results in increased expression of HMOX1 protein]; brusatol inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of HMOX1 protein]; dendropanoxide inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of HMOX1 protein]; GSK3B protein affects the reaction [Cadmium results in increased expression of HMOX1 protein]; Lithium Chloride promotes the reaction [Cadmium results in increased expression of HMOX1 protein]; Melatonin inhibits the reaction [Cadmium affects the expression of HMOX1 mRNA]; NFE2L2 protein affects the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of HMOX1 protein]; rottlerin inhibits the reaction [Cadmium results in increased expression of HMOX1 protein]; SB 216763 promotes the reaction [Cadmium results in increased expression of HMOX1 protein]; Silymarin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of HMOX1 protein]; Triiodothyronine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of HMOX1 protein] | PMID:16948784 PMID:27658547 PMID:34695510 PMID:35384154 PMID:36718047 PMID:36868496 PMID:37949422 | | ||||||||||||||||||||||
| Go Back to source page | Continue to Ontology report |