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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730895
Species: Mus musculus
RGD Object: Gene
Symbol: Il18
Name: interleukin 18
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il18affects expressionEXP 6480464CTDTetrachlorodibenzodioxin affects the expression of IL18 mRNAPMID:12167310 PMID:21570461
Il18multiple interactionsEXP 6480464CTDKL protein inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL18 mRNA]]; KL protein inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL18 protein]]; Tetrachlorodibenzodioxin promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL18 mRNA]; Tetrachlorodibenzodioxin promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of IL18 protein]PMID:29885354
Il18affects expressionISOIl18 (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin affects the expression of IL18 mRNAPMID:22298810
Il18affects expressionISOIL18 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin affects the expression of IL18 mRNAPMID:22298810
Il18decreases expressionISOIl18 (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of IL18 mRNAPMID:33387578
Il18decreases expressionISOIL18 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in decreased expression of IL18 mRNAPMID:16039398
Il18increases expressionISOIl18 (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin results in increased expression of IL18 mRNAPMID:20959002 PMID:21215274 PMID:34747641
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