GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Il18 | increases expression | ISO | Il18 (Rattus norvegicus) | 6480464 | CTD | Aldosterone results in increased expression of IL18 mRNA; Aldosterone results in increased expression of IL18 protein | PMID:18660453 | Il18 | multiple interactions | ISO | Il18 (Rattus norvegicus) | 6480464 | CTD | [cyclo(Trp-Asp-Pro-Val-Leu) binds to and results in decreased activity of EDNRA protein] inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]; [EDN1 protein binds to and results in increased activity of EDNRA protein] promotes the reaction [Aldosterone results in increased expression of IL18 mRNA]; AGT protein alternative form promotes the reaction [Aldosterone results in increased expression of IL18 mRNA]; Bezafibrate inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]; Cycloheximide inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]; eplerenone inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]; exoenzyme C3, Clostridium botulinum inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]; fasudil inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]]; olmesartan inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]; pioglitazone inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]; prolinedithiocarbamate inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]; Simvastatin inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]; SN50 peptide inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]; Spironolactone inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA] | PMID:18660453 | | ||||||||||||||||||||||
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