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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730893
Species: Mus musculus
RGD Object: Gene
Symbol: Nfkb1
Name: nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105
Acc ID: CHEBI:47977
Term: 2-amino-2-deoxy-D-glucopyranose
Definition: A D-glucosamine whose structure comprises D-glucopyranose having an amino substituent at position 2.
Chemical ID: MESH:D005944
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nfkb1multiple interactionsEXP 6480464CTDGlucosamine analog inhibits the reaction [Lipopolysaccharides results in increased expression of NFKB1 protein]PMID:18205790
Nfkb1decreases activityISONfkb1 (Rattus norvegicus)6480464CTDGlucosamine results in decreased activity of NFKB1 proteinPMID:20737476
Nfkb1multiple interactionsISONFKB1 (Homo sapiens)6480464CTDGlucosamine inhibits the reaction [Hydrogen Peroxide results in increased expression of and results in increased localization of NFKB1 protein]; Glucosamine inhibits the reaction [IL1B protein results in increased localization of NFKB1 protein]; Glucosamine inhibits the reaction [IL1B results in increased degradation of NFKB1 protein]; Glucosamine inhibits the reaction [NFKB1 results in increased degradation of RELA protein]; Glucosamine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of NFKB1 protein]PMID:12681956 PMID:16431966 PMID:16822504 PMID:17498959 PMID:18036590
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