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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730893
Species: Mus musculus
RGD Object: Gene
Symbol: Nfkb1
Name: nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105
Acc ID: CHEBI:28694
Term: copper atom
Definition: A copper group element atom that has formula Cu.
Chemical ID: MESH:D003300
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nfkb1increases activityISONfkb1 (Rattus norvegicus)6480464CTDCopper results in increased activity of NFKB1 proteinPMID:16987042
Nfkb1increases expressionISONfkb1 (Rattus norvegicus)6480464CTDCopper deficiency results in increased expression of NFKB1 mRNAPMID:17418555
Nfkb1multiple interactionsISONfkb1 (Rattus norvegicus)6480464CTDtempol inhibits the reaction [Copper results in increased activity of NFKB1 protein]PMID:16987042
Nfkb1multiple interactionsISONFKB1 (Homo sapiens)6480464CTD[Chelating Agents binds to Copper] which results in increased expression of NFKB1 mRNA; [Disulfiram binds to Copper] which results in increased expression of NFKB1 mRNA; Copper inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine affects the localization of NFKB1 protein]PMID:18615482 PMID:24690739 PMID:30911355
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