GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Nfkb1 | increases activity | ISO | Nfkb1 (Rattus norvegicus) | 6480464 | CTD | Copper results in increased activity of NFKB1 protein | PMID:16987042 | Nfkb1 | increases expression | ISO | Nfkb1 (Rattus norvegicus) | 6480464 | CTD | Copper deficiency results in increased expression of NFKB1 mRNA | PMID:17418555 | Nfkb1 | multiple interactions | ISO | Nfkb1 (Rattus norvegicus) | 6480464 | CTD | tempol inhibits the reaction [Copper results in increased activity of NFKB1 protein] | PMID:16987042 | Nfkb1 | multiple interactions | ISO | NFKB1 (Homo sapiens) | 6480464 | CTD | [Chelating Agents binds to Copper] which results in increased expression of NFKB1 mRNA; [Disulfiram binds to Copper] which results in increased expression of NFKB1 mRNA; Copper inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine affects the localization of NFKB1 protein] | PMID:18615482 PMID:24690739 PMID:30911355 | |
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