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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730893
Species: Mus musculus
RGD Object: Gene
Symbol: Nfkb1
Name: nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105
Acc ID: CHEBI:17634
Term: D-glucose
Definition: A glucose with D-configuration.
Chemical ID: MESH:D005947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nfkb1multiple interactionsEXP 6480464CTD[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of NFKB1 protein; Glucose results in increased activity of and affects the localization of NFKB1 protein; INO 1001 inhibits the reaction [Glucose results in increased activity of and affects the localization of NFKB1 protein]; NFKB1 protein inhibits the reaction [SOD1 protein promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of PTGS2 protein]]; SOD1 protein inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of and results in increased activity of NFKB1 protein]PMID:16395278 PMID:17065336
Nfkb1increases expressionISONFKB1 (Homo sapiens)6480464CTDGlucose results in increased expression of NFKB1 mRNA; Glucose results in increased expression of NFKB1 proteinPMID:18180316 PMID:21682256
Nfkb1multiple interactionsISONFKB1 (Homo sapiens)6480464CTD[Glucose results in increased susceptibility to sodium arsenite] which results in increased expression of NFKB1 mRNA; [osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in increased expression of NFKB1 mRNA; Polyphenols inhibits the reaction [Glucose results in increased expression of NFKB1 mRNA]PMID:21682256 PMID:28264687 PMID:32613381
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