GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | NFKB1 | affects localization | EXP | | 6480464 | CTD | Doxorubicin affects the localization of NFKB1 protein | PMID:15870702 | NFKB1 | affects response to substance | EXP | | 6480464 | CTD | NFKB1 protein affects the susceptibility to Doxorubicin | PMID:17912235 | NFKB1 | decreases expression | EXP | | 6480464 | CTD | Doxorubicin results in decreased expression of NFKB1 mRNA | PMID:26969377 PMID:29803840 | NFKB1 | increases activity | EXP | | 6480464 | CTD | Doxorubicin results in increased activity of NFKB1 protein | PMID:15571967 | NFKB1 | increases expression | EXP | | 6480464 | CTD | Doxorubicin results in increased expression of NFKB1 mRNA; Doxorubicin results in increased expression of NFKB1 protein | PMID:16001973 PMID:17912235 | NFKB1 | increases localization | EXP | | 6480464 | CTD | Doxorubicin results in increased localization of NFKB1 protein | PMID:18463201 | NFKB1 | multiple interactions | EXP | | 6480464 | CTD | 1'-acetoxychavicol acetate inhibits the reaction [Doxorubicin results in increased activity of NFKB1 protein]; [Doxorubicin co-treated with cordycepin] results in decreased expression of NFKB1 protein; [Doxorubicin co-treated with Resveratrol] results in decreased expression of NFKB1 mRNA; [NFKB1 protein binds to RELA protein] which affects the susceptibility to Doxorubicin; Doxorubicin results in increased activity of [NFKB1 protein binds to RELA protein]; NFKB1 protein affects the reaction [Doxorubicin results in decreased expression of DDIT3 protein]; NFKB1 protein affects the reaction [Doxorubicin results in increased expression of BCL2L1 protein]; NFKB1 protein affects the reaction [Doxorubicin results in increased expression of HIF1A protein]; NFKB1 protein affects the reaction [Doxorubicin results in increased expression of TP53 protein]; NFKB1 protein affects the reaction [Doxorubicin results in increased expression of VEGFA protein]; Simvastatin promotes the reaction [Doxorubicin results in increased localization of and results in increased activity of NFKB1 protein]; Simvastatin promotes the reaction [Doxorubicin results in increased localization of NFKB1 protein]; Sirolimus inhibits the reaction [Doxorubicin results in increased activity of NFKB1 protein]; TP53 protein affects the reaction [Doxorubicin results in increased expression of NFKB1 protein] | PMID:15555623 PMID:15571967 PMID:15905586 PMID:16322301 PMID:17912235 PMID:18463201 PMID:26969377 PMID:35186504 | NFKB1 | increases expression | ISO | Nfkb1 (Rattus norvegicus) | 6480464 | CTD | Doxorubicin results in increased expression of NFKB1 protein | PMID:31376360 | NFKB1 | multiple interactions | ISO | Nfkb1 (Rattus norvegicus) | 6480464 | CTD | Doxorubicin results in increased expression of and results in increased activity of NFKB1 protein; Nicorandil inhibits the reaction [Doxorubicin results in increased expression of NFKB1 protein] | PMID:15667795 PMID:31376360 | | ||||||||||||||||||||||
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