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GENE - TERM ANNOTATION REPORT

RGD ID: 730890
Species: Homo sapiens
RGD Object: Gene
Symbol: NCOR1
Name: nuclear receptor corepressor 1
Acc ID: DOID:12858
Term: Huntington's disease
Definition: A neurodegenerative disease that has_material_basis_in autosomal dominant inheritance and is characterized by unwanted choreatic movements, behavioral and psychiatric disturbances and dementia and has_material_basis_in expansion of CAG triplet repeats (glutamine) resulting in neuron degeneration affecting muscle coordination, cognitive abilities. (DO)
Definition Source(s): http://en.wikipedia.org/wiki/Huntington_disease "DO" "DO", http://www.orpha.net/consor/cgi-bin/Disease_Search.php?lng=EN&data_id=118&Disease_Disease_Search_diseaseGroup=huntington&Disease_Disease_Search_diseaseType=Pat&Disease(s)%20concerned=Huntington-disease&title=Huntington-disease&search=Disease_Search_Simple "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NCOR1 IEP 5688338RGDprotein:decreased expression:temporal cortex, neuron, nucleus (human) 
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