GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Prkaa2 | multiple interactions | EXP | | 6480464 | CTD | [[PRKAA1 gene mutant form co-treated with PRKAA2 gene mutant form] affects the susceptibility to [Glucose co-treated with S 4048]] which results in decreased abundance of Adenosine Triphosphate; [[PRKAA1 gene mutant form co-treated with PRKAA2 gene mutant form] affects the susceptibility to [Glucose co-treated with S 4048]] which results in increased abundance of Glucose-6-Phosphate; [PRKAA1 gene mutant form co-treated with PRKAA2 gene mutant form] affects the susceptibility to [Glucose co-treated with S 4048]; Glucose results in decreased phosphorylation of and results in decreased activity of PRKAA2 protein; PRKAA2 protein affects the reaction [AICA ribonucleotide inhibits the reaction [AKT1 protein mutant form affects the susceptibility to Glucose deficiency]]; PRKAA2 protein affects the reaction [Resveratrol inhibits the reaction [Glucose results in decreased expression of SIRT1 protein]] | PMID:15806154 PMID:19052259 PMID:23090186 PMID:31974165 | Prkaa2 | affects response to substance | ISO | Prkaa2 (Rattus norvegicus) | 6480464 | CTD | PRKAA2 protein mutant form affects the susceptibility to Glucose deficiency | PMID:15806154 | Prkaa2 | decreases expression | ISO | Prkaa2 (Rattus norvegicus) | 6480464 | CTD | Glucose results in decreased expression of PRKAA2 mRNA; Glucose results in decreased expression of PRKAA2 protein | PMID:24349266 | Prkaa2 | multiple interactions | ISO | PRKAA2 (Homo sapiens) | 6480464 | CTD | [resveratrol inhibits the reaction [Glucose results in decreased phosphorylation of and results in decreased activity of PRKAA2 protein]] which results in decreased abundance of Triglycerides; [resveratrol results in increased activity of SIRT1 protein] inhibits the reaction [Glucose results in decreased phosphorylation of and results in decreased activity of PRKAA2 protein]; Glucose results in decreased phosphorylation of and results in decreased activity of PRKAA2 protein; PRKAA2 protein promotes the reaction [resveratrol inhibits the reaction [Glucose results in increased abundance of Triglycerides]]; PRKAA2 protein promotes the reaction [SIRT1 protein inhibits the reaction [Glucose results in decreased phosphorylation of ACACA protein]]; PRKAA2 protein promotes the reaction [SIRT1 protein inhibits the reaction [Glucose results in increased abundance of Triglycerides]]; PRKAA2 protein promotes the reaction [SIRT1 protein inhibits the reaction [Glucose results in increased expression of FASN protein]]; resveratrol inhibits the reaction [Glucose results in decreased phosphorylation of and results in decreased activity of PRKAA2 protein]; SIRT1 protein promotes the reaction [[resveratrol inhibits the reaction [Glucose results in decreased phosphorylation of and results in decreased activity of PRKAA2 protein]] which results in decreased abundance of Triglycerides] | PMID:18482975 | | ||||||||||||||||||||||
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