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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730886
Species: Homo sapiens
RGD Object: Gene
Symbol: CREB1
Name: cAMP responsive element binding protein 1
Acc ID: CHEBI:29474
Term: (S)-3,5-dihydroxyphenylglycine
Definition: A glycine derivative that is L-alpha-phenylglycine substituted at positions 3 and 5 on the phenyl ring by hydroxy groups.
Chemical ID: MESH:C079215
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CREB1increases phosphorylationISOCreb1 (Rattus norvegicus)6480464CTD3,5-dihydroxyphenylglycine results in increased phosphorylation of CREB1 proteinPMID:16600209
CREB1increases phosphorylationISOCreb1 (Mus musculus)6480464CTD3,5-dihydroxyphenylglycine results in increased phosphorylation of CREB1 proteinPMID:16600209
CREB1multiple interactionsISOCreb1 (Rattus norvegicus)6480464CTD6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [N-(4-chloro-2-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)phenyl)-2-hydroxybenzamide promotes the reaction [3,5-dihydroxyphenylglycine results in increased phosphorylation of CREB1 protein]]; N-(4-chloro-2-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)phenyl)-2-hydroxybenzamide promotes the reaction [3,5-dihydroxyphenylglycine results in increased phosphorylation of CREB1 protein]PMID:16600209
CREB1multiple interactionsISOCreb1 (Mus musculus)6480464CTD6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [N-(4-chloro-2-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)phenyl)-2-hydroxybenzamide promotes the reaction [3,5-dihydroxyphenylglycine results in increased phosphorylation of CREB1 protein]]; N-(4-chloro-2-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)phenyl)-2-hydroxybenzamide promotes the reaction [3,5-dihydroxyphenylglycine results in increased phosphorylation of CREB1 protein]PMID:16600209
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