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GENE - TERM ANNOTATION REPORT

RGD ID: 730881
Species: Homo sapiens
RGD Object: Gene
Symbol: HRAS
Name: HRas proto-oncogene, GTPase
Acc ID: DOID:0111359
Term: large congenital melanocytic nevus
Definition: A skin disease characterized by the presence at birth of a pigmented skin lesion composed of melanocytes of more than 20 cm in projected adult diameter that has_material_basis_in somatic mutation in the NRAS gene on chromosome 11p15.5. (DO)
Definition Source(s): https://www.ncbi.nlm.nih.gov/pubmed/18671780 "DO" "DO", https://www.ncbi.nlm.nih.gov/pubmed/23392294 "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
HRAS IAGP 7240710OMIM  
HRAS EXP 11554173CTDCTD Direct Evidence: marker/mechanism 
HRAS IAGP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Large congenital melanocytic nevusPMID:25741868
HRAS IAGP (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Large congenital melanocytic nevusPMID:25741868 PMID:28492532
HRAS IAGP (Homo sapiens) or (Homo sapiens) or (Homo sapiens) or (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Congenital giant melanocytic nevus | ClinVar Annotator: match by term: Large congenital melanocytic nevusPMID:24033266 PMID:25741868 PMID:28492532
HRAS IAGP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Congenital giant melanocytic nevusPMID:16170316 PMID:16372351 PMID:16443854 PMID:16835863 PMID:17601930 PMID:17979197 PMID:18042262 PMID:20979192 PMID:21686750 PMID:21834037 PMID:21850009 PMID:22317973 PMID:22420426 PMID:23093928 PMID:23751039 PMID:24169525 PMID:24224811 PMID:24803665 PMID:25741868 PMID:26619011 PMID:27195699 PMID:27589201 PMID:28027064 PMID:28492532
HRAS IAGP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Congenital giant melanocytic nevusPMID:16170316 PMID:16329078 PMID:18042262 PMID:21438134 PMID:21850009 PMID:22190897 PMID:23093928 PMID:23429430 PMID:23487764 PMID:23751039 PMID:24224811 PMID:25741868 PMID:26561417 PMID:28371260 PMID:28492532
HRAS IAGP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Congenital giant melanocytic nevusPMID:16170316 PMID:16372351 PMID:16443854 PMID:16835863 PMID:17601930 PMID:18039947 PMID:18042262 PMID:19382114 PMID:21850009 PMID:22420426 PMID:22499344 PMID:22683711 PMID:22926243 PMID:23429430 PMID:24033266 PMID:25157968 PMID:25741868 PMID:26619011 PMID:28027064 PMID:28492532 PMID:31394527
HRAS IAGP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Congenital giant melanocytic nevusPMID:16329078 PMID:16372351 PMID:168335863 PMID:16835863 PMID:17211612 PMID:17384584 PMID:18042262 PMID:19213030 PMID:19255327 PMID:19773371 PMID:21438134 PMID:21495179 PMID:21850009 PMID:23093928 PMID:23406027 PMID:23429430 PMID:24033266 PMID:25157968 PMID:25326635 PMID:25741868 PMID:26619011 PMID:28492532 PMID:29493581
HRAS IAGP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Large congenital melanocytic nevusPMID:21403836 PMID:24033266 PMID:25346259 PMID:25741868 PMID:28492532
HRAS IAGP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Large congenital melanocytic nevusPMID:25741868 PMID:25742471 PMID:28492532
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