GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | SOD2 | affects response to substance | EXP | | 6480464 | CTD | SOD2 protein polymorphism affects the susceptibility to Methotrexate | PMID:25330300 | SOD2 | decreases expression | EXP | | 6480464 | CTD | Methotrexate results in decreased expression of SOD2 mRNA | PMID:19192274 | SOD2 | increases expression | EXP | | 6480464 | CTD | Methotrexate results in increased expression of SOD2 mRNA; Methotrexate results in increased expression of SOD2 protein | PMID:25575725 | SOD2 | multiple interactions | EXP | | 6480464 | CTD | dorsomorphin inhibits the reaction [Methotrexate results in increased expression of SOD2 mRNA]; Methotrexate promotes the reaction [CREB1 protein binds to SOD2 promoter]; PRKAA1 mutant form inhibits the reaction [Methotrexate results in increased expression of SOD2 mRNA]; PRKAA1 mutant form inhibits the reaction [Methotrexate results in increased expression of SOD2 protein]; PRKAA2 mutant form inhibits the reaction [Methotrexate results in increased expression of SOD2 mRNA]; PRKAA2 mutant form inhibits the reaction [Methotrexate results in increased expression of SOD2 protein]; SOD2 protein polymorphism affects the reaction [Methotrexate affects the expression of BAX mRNA]; SOD2 protein polymorphism affects the reaction [Methotrexate affects the expression of BCL2 mRNA]; SOD2 protein polymorphism affects the reaction [Methotrexate affects the expression of CAT mRNA]; SOD2 protein polymorphism affects the reaction [Methotrexate affects the expression of SOD2 mRNA]; SOD2 protein polymorphism affects the reaction [Methotrexate results in increased expression of CASP3 mRNA]; SOD2 protein polymorphism affects the reaction [Methotrexate results in increased expression of CASP3 protein]; SOD2 protein polymorphism affects the reaction [Methotrexate results in increased expression of CASP8 mRNA]; SOD2 protein polymorphism affects the reaction [Methotrexate results in increased expression of CASP8 protein]; SOD2 protein polymorphism affects the reaction [Methotrexate results in increased expression of GPX1 mRNA] | PMID:25330300 PMID:25575725 | SOD2 | increases expression | ISO | Sod2 (Mus musculus) | 6480464 | CTD | Methotrexate results in increased expression of SOD2 protein | PMID:25575725 | |
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