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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730872
Species: Homo sapiens
RGD Object: Gene
Symbol: SOD2
Name: superoxide dismutase 2
Acc ID: CHEBI:34631
Term: chlorpyrifos
Definition: An organic thiophosphate that is O,O-diethyl hydrogen phosphorothioate in which the hydrogen of the hydroxy group has been replaced by a 3,5,6-trichloropyridin-2-yl group.
Chemical ID: MESH:D004390
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SOD2affects expressionEXP 6480464CTDChlorpyrifos affects the expression of SOD2 proteinPMID:24793810
SOD2decreases expressionISOSod2 (Mus musculus)6480464CTDChlorpyrifos results in decreased expression of SOD2 mRNAPMID:37019170
SOD2decreases expressionISOSod2 (Rattus norvegicus)6480464CTDChlorpyrifos results in decreased expression of SOD2 mRNA; Chlorpyrifos results in decreased expression of SOD2 proteinPMID:19440498 PMID:22714038 PMID:31823260
SOD2increases expressionISOSod2 (Mus musculus)6480464CTDChlorpyrifos results in increased expression of SOD2 mRNAPMID:32955216
SOD2increases expressionISOSod2 (Rattus norvegicus)6480464CTDChlorpyrifos results in increased expression of SOD2 mRNAPMID:20691718
SOD2multiple interactionsISOSod2 (Mus musculus)6480464CTDHydrogen inhibits the reaction [Chlorpyrifos results in increased expression of SOD2 mRNA]PMID:32955216
SOD2multiple interactionsISOSod2 (Rattus norvegicus)6480464CTDAcetylcysteine inhibits the reaction [Chlorpyrifos results in decreased expression of SOD2 protein]; Plant Extracts inhibits the reaction [Chlorpyrifos results in decreased expression of SOD2 mRNA]PMID:22714038 PMID:31823260
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